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Xiaoye Schneider-Yin Selected Research

Erythropoietic Protoporphyria

1/2021Repurposing of glycine transport inhibitors for the treatment of erythropoietic protoporphyria.
1/2020Delivery of oligonucleotides to bone marrow to modulate ferrochelatase splicing in a mouse model of erythropoietic protoporphyria.
1/2020Increased phototoxic burn tolerance time and quality of life in patients with erythropoietic protoporphyria treated with afamelanotide - a three years observational study.
11/2019Delta-aminolevulinic acid synthase 2 expression in combination with iron as modifiers of disease severity in erythropoietic protoporphyria.
1/2017Modeling the ferrochelatase c.315-48C modifier mutation for erythropoietic protoporphyria (EPP) in mice.
1/2017Disturbed iron metabolism in erythropoietic protoporphyria and association of GDF15 and gender with disease severity.
1/2015In ferrochelatase-deficient protoporphyria patients, ALAS2 expression is enhanced and erythrocytic protoporphyrin concentration correlates with iron availability.
1/2015Afamelanotide (CUV1647) in dermal phototoxicity of erythropoietic protoporphyria.
10/2013Iron availability modulates aberrant splicing of ferrochelatase through the iron- and 2-oxoglutarate dependent dioxygenase Jmjd6 and U2AF(65.).
12/2010Exacerbation of erythropoietic protoporphyria by hyperthyroidism.
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Xiaoye Schneider-Yin Research Topics

Disease

12Erythropoietic Protoporphyria
01/2021 - 05/2003
6Phototoxic Dermatitis (Phototoxicity)
11/2019 - 03/2009
6Acute Intermittent Porphyria (Porphyria, Acute)
03/2015 - 01/2002
4Iron Deficiencies
11/2019 - 10/2013
3Hypochromic Anemia (Chlorosis)
11/2019 - 01/2015
3Variegate Porphyria (Protoporphyrinogen Oxidase Deficiency)
03/2015 - 08/2006
2Inflammation (Inflammations)
08/2018 - 01/2017
2Anemia
01/2017 - 01/2017
2Porphyrias (Porphyria)
04/2009 - 08/2006
1Acute Erythroblastic Leukemia (Erythroleukemia)
01/2021
1Burns
01/2020
1Gastrointestinal Diseases (Functional Gastrointestinal Disorders)
08/2018
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
08/2018
1Hemorrhage
08/2018
1Colonic Neoplasms (Colon Cancer)
07/2018
1Chronic Disease (Chronic Diseases)
01/2017
1Liver Diseases (Liver Disease)
01/2017
1Pain (Aches)
01/2017
1Liver Neoplasms (Liver Cancer)
03/2015
1Graves Disease (Basedow Disease)
12/2010
1Hepatocellular Carcinoma (Hepatoma)
09/2010
1Lichen Sclerosus et Atrophicus (Lichen Sclerosus)
08/2010
1Erythropoietic Porphyria (Congenital Erythropoietic Porphyria)
02/2010
1Endometrial Neoplasms (Endometrial Cancer)
03/2009

Drug/Important Bio-Agent (IBA)

11Heme (Haem)IBA
11/2019 - 03/2002
8Ferrochelatase (Heme Synthetase)IBA
01/2020 - 05/2003
7protoporphyrin IXIBA
01/2021 - 03/2009
6EnzymesIBA
11/2019 - 09/2010
6Hydroxymethylbilane Synthase (Porphobilinogen Deaminase)IBA
03/2015 - 01/2002
4IronIBA
11/2019 - 01/2015
3afamelanotideIBA
01/2020 - 01/2015
3Protoporphyrinogen Oxidase (Protox)IBA
03/2015 - 08/2006
2AcidsIBA
01/2015 - 03/2009
1Glycine (Aminoacetic Acid)FDA LinkGeneric
01/2021
1OligonucleotidesIBA
01/2020
1Aminolevulinic Acid (Levulan)FDA Link
11/2019
1Ferritins (Ferritin)IBA
11/2019
1Leukocyte L1 Antigen Complex (Calgranulin)IBA
08/2018
1Formaldehyde (Formol)FDA Link
07/2018
1ParaffinIBA
07/2018
1Reactive Oxygen Species (Oxygen Radicals)IBA
01/2017
1Melanins (Melanin)IBA
01/2017
1Type 1 Melanocortin ReceptorIBA
01/2017
1AntioxidantsIBA
01/2017
1IsoenzymesIBA
01/2015
1DioxygenasesIBA
10/2013
1Splicing Factor U2AFIBA
10/2013
1Small Interfering RNA (siRNA)IBA
10/2013
1Proteins (Proteins, Gene)FDA Link
10/2013
1Iodide Peroxidase (Deiodinase)IBA
12/2010
1Thyrotropin (Thyroid-Stimulating Hormone)FDA Link
12/2010
1Thyroxine (Levothyroxine)FDA LinkGeneric
12/2010
1Triiodothyronine (Liothyronine)FDA LinkGeneric
12/2010
1AntibodiesIBA
12/2010
1Thyrotropin Receptors (Thyrotropin Receptor)IBA
12/2010
1Acute Hepatic PorphyriaIBA
09/2010
1Uroporphyrinogen III Synthetase (Uroporphyrinogen-III Synthase)IBA
02/2010
1Pharmaceutical PreparationsIBA
04/2009
1hypericinIBA
03/2009

Therapy/Procedure

1Liver Transplantation
05/2003